作　　者： ; ; ; ; ; ; ; ;

机构地区： 深圳大学师范学院化学生物系

出　　处： 《无机化学学报》 2003年第6期645-649,共5页

摘　　要： Two polypyridyl ligands DCHIP (2 hydro 3,5 dichlorophenyl imidazo phenanthroline),MDHIP(2,4 dihydrophenyl imidazophenanthroline) and their ruthenium?complexes [Ru(phen)2 MDHIP]2+and [Ru(phen)2DCHIP]2+were prepared. Their DNA binding properties were studied by spectroscopic methods and viscosity measurements. The results indicated that the complexes both bound to DNA by partial intercalation mode, but [Ru(phen)2DCHIP]2+exhibited stronger binding affinity for DNA than [Ru(phen)2 MDHIP]2+due to the different planarities and steric effects of ligands. On the other hand, after binding to DNA, the fluorescence intensity of [Ru(phen)2MDHIP]2+decreased, while the fluorescence intensity of [Ru(phen)2 DCHIP]2+increased. Two polypyridyl ligands DCHIP (2-hydro-3, 5-dichlorophenyl-imidazo[4, 5-f] [1, 10] phenanthroline), MDHIP (2, 4-dihydrophenyl-imidazo[4, 5-f][1,10] phenanthroline) and their ruthenium (II) complexes [Ru(phen)(2)MDHIP](2+) and [Ru(phen)(2)DCHIP](2+) were prepared. Their DNA-binding properties were studied by spectroscopic methods and viscosity measurements. The results indicated that the complexes both bound to DNA by partial intercalation mode, but [Ru(phen)(2)DCHIP](2+) exhibited stronger binding affinity for DNA than [Ru(phen)(2)MDHIP](2+) due to the different planarities and steric effects of ligands. On the other hand, after binding to DNA, the fluorescence intensity of [Ru(phen)(2)MDHIP](2+) decreased, while the fluorescence intensity of [Ru(phen)(2) DCHIP](2+) increased.

关 键 词： 钌 多吡啶配合物 配体 作用机制 荧光性质 八面体构型 插入模式

领　　域： [生物学] [理学] [理学]