作　　者： ; ; ; ; ; ;

机构地区： 武汉大学人民医院

出　　处： 《微循环学杂志》 2003年第4期42-44,共3页

摘　　要： 目的 :对中国汉族人群极低密度脂蛋白受体 (VLDL R )基因CGG重复序列多态性与血脂水平及心脑血管病的相关性进行研究。方法 :检测湖北地区 75例冠心病 (CHD)、65例动脉粥样硬化性脑梗死 (ABI)和 160例正常人CGG重复序列 ,并分析各组血脂水平。结果 :共检出CGG重复次数为 5、8、9、11的 4种等位基因及 5 /5、5 /8、8/8、8/9、9/9、5 /9、8/11、5 /11等 8种基因型。CHD组与对照组、ABI组与对照组比较 ,VLDL R等位基因频率以及基因型频率分布无统计学差异 (P >0 .0 5 )。在CHD组和ABI组中 ,五个亚组间TC、TG、HDL -C、LDL -C、ApoAⅠ、ApoB及Lp(a)水平均无显著性差异 (P >0 .0 5 )。结论 :VLDL R基因多态性与人群中的血脂水平无关联 ,与心脑血管病 (CCVD)也没有关联。 Objective: To investigate the distribution pattern of the CGG triplet of VLDL R gene in Chinese Han nationality and its relation with blood lipid level.Method: In Hubei region, there were including 75 cases with coronary heart disease (CHD), 65 cases with atherosclerotic brain infarct (ABI), and 160 healthy controls were studied.Results: 4 alleles and 8 gene types were found.There were no statistically significant differences ( P >0.05) in VLDL R gene allele and genotype frequencies between CHD and normal controls,also ABI and normal controls.When the subjects were divided into 5 subgroups according to VLDL R genotype, the differences among the subgroups were not statistically significant ( P >0.05).Conclusion: VLDL R gene polymorphism does not obvious influence on lipid metabolism and CCVD.

关 键 词： 中国 汉族人群 极低密度脂蛋白受体 基因多态性 血脂 相关性 跨膜蛋白 心脑血管病

领　　域： [生物学]