作　　者： ; ; ; ;

机构地区： 广东省实验动物监测所

出　　处： 《上海实验动物科学》 2003年第3期131-134,共4页

摘　　要： 为了解人工饲养条件下猕猴脏器自发病变的发生情况,建立猕猴自发病变的病理图谱。采用常规组织学技术结合部分特殊染色,观察了各个年龄阶段的65例猕猴消化道多个部位和唾液腺、胆囊和胰腺的组织病理变化。结果发现92.3%猕猴的消化系统组织存在不同程度的病变,包括各种炎性细胞浸润,消化道黏膜的变性、坏死,消化腺上皮的萎缩、增生等共32种。消化系统9种器官中,器官总的病变检出率以大肠、颊囊、小肠最高,食道和唾液腺最低。多数消化道组织病变程度和病变发生率随年龄增长增加。结果提示,应加强药物安全性评价实验中动物自发病变的病理监测。 To study the histopathological changes in digestive system spontaneous lesions of breeding macaca mulatta, the tongue, cheek pouch, esophagus, stomach, intestine, salivary glands, gall bladder and pancreas samples from the monkey of 2～20 years old were investigated by routine histological technique. The results showed that various spontaneous lesions including inflammatory cell infiltration, degenerations and necroses in mucosa,atrophy and proliferations in digestive glands, totaling 32 kinds in different degrees, were found in 92.3% of the monkeys. The organ total detectable rate is higher in large intestine, check pouch and small intestine, and lower in esophagus and salivary gland.The degree and the frequency of lesions increased with age. It is suggested that spontaneous lesions should be monitored in safety estimation experiment of new medicine.

关 键 词： 猕猴 消化系统 自发病变 组织病理学

领　　域： [农业科学] [农业科学] [农业科学] [生物学]