作　　者： ; ;

机构地区： 遵义医学院公共卫生学院

出　　处： 《大家健康（学术版）》 2013年第15期2-3,共2页

摘　　要： 目的:探索利谷隆致SD雄性子代大鼠的生殖发育毒性影响。方法:分别于SD大鼠孕期妊娠期连续灌服花生油和利谷隆染毒后,获得子鼠。实验分对照组和利谷隆组,子代雄性大鼠生长至性成熟后,行精子分析,取生殖组织进行HE染色,睾丸行透射电镜观察。结果:与对照组比较,利谷隆组子代雄性小鼠精子数量显著降低(P<0.01)。利谷隆组睾丸组织经HE染色发现部分生精小管结构破坏,生精细胞及精子溢出,电镜发现间质细胞线粒体肿胀,内质网扩张。结论:利谷隆通过损伤睾丸组织影响SD雄性子代大鼠的生殖发育。 Objective: To explore the reproductive toxicity of linuron on F1 male rats. Method: Pregnant female rats were exposed to linuron and peanut oil everyday during the period of gestation day ( GD) ,and were randomly divided into linuron group and control group. After maturation,the semen from F1 male rats was analyzed and HE stain and transmission electron microscopy were used to detecte the tissue development of testicle,prostate,epididymis,spermatica from F1 male rats. Result: Semen analysis showed that in the linuron group,the number of sperm significantly decreased ( P < 0. 01) . There were some structural damage in seminiferous tubules,some spermatogenic cells and sperm overflowed and some plasma cells infiltrated in the testicle. Conclusion: Our results demonstrated that linuron inducing testicle development malformation,significant decrease of sperm and increase of sperm malformation in F1 male rats.

关 键 词： 利谷隆 生殖毒性 雄性子代大鼠 透射电镜

领　　域： [环境科学与工程]