作　　者： ; ; ;

机构地区： 南京军区南京总医院

出　　处： 《卫生研究》 2002年第6期481-483,共3页

摘　　要： 维生素利用一直是科学家及医学工作者所热衷的主题 ,与人类健康息息相关。目前已发现某些水溶性维生素的吸收过程是由专有的转运体介导的。本文主要综述了泛酸、生物素、硫辛酸共用的转运体的基因结构 ,蛋白质结构、组织分布、克隆表达后的功能特点、染色体定位及转运过程的调控 ,此转运体因三种维生素共用而称多维生素转运体 (SMVT) ,有着明显的底物特异性 ,广泛的存在于机体各组织中 ,可能是Na+依赖的葡萄糖载体家族成员 ,由蛋白激酶C介导的通道调节 ,其基因位于人染色体 2p2 3。 Vitamin utilization is a topic that appears to be pursued ardently by scientists and medical practitioners,which is related to human health.Now it has been found that some water\|soluble vitamin absorption are mediated by special transporter.This article will review gene and protein structure,tissue distribution,and functional characterization following expression,chromosomal localization of vitamin transporter which transports pantothenate,biotin and lipoate,as well as regulation in the transporting progress.This transporter is called Na\++\|dependent multivitamin transporter(SMVT) shared with three kinds of vitamin, which have distinct substrate specificity,and widely exists in the various tissues,may belong to Na\++\|dependent glucose transporter family and be under the regulation of an intracelluar PKC\|mediated pathway.The SMVT gene locates on chromosome 2p23.This finding provides a new way to study the dificiency and the utilization of vitamin.

关 键 词： 多维生素转运体 基因结构 蛋白质结构 组织来源 功能特点 染色体定位

领　　域： [生物学]