作　　者： ; ;

机构地区： 重庆市涪陵区畜牧食品局

出　　处： 《四川畜牧兽医》 2002年第12期35-36,共2页

摘　　要： 选择给药后血清中超氧化物歧化酶(SOD)活力升高率为药效学指标,对动物保健中药复方制剂“延命散”进行了量效关系研究。结果表明:在给药剂量1.038×103mg/kg体重与2×104mg/kg体重之间,“延命散”对血清中SOD活力的升高率呈现一定的量效关系。而当剂量大于2×104mg/kg体重时,随着剂量的增大,SOD活力的升高率逐渐降低,甚至出现负增长,给药剂量达到1×105mg/kg体重时,SOD活力下降到340.40±63.18Nu/mL,显著低于空白对照组(P<0.05),SOD活力降低了18.55%,表现出对酶活力的抑制作用。由此可见,在中兽药的研究和开发中,确定科学合理的给药剂量,进行量效关系的研究至关重要。 Abstract:The relationship between the dose of oral administration of YAN MINGSAN and the increased percentage of the SOD activity in serum was studied.The results showed that the drug-contained serum had dose-dependent relationship in effect of the increased percentage of the SOD activity in serum after oral administration of CHONGKANG,the dose of which was between1.038×10 3 mg /kg body weight and2×10 4 mg /kg body weight.While the dose surpassed2×10 4 mg /kg body weight,the increased percentage of SOD activity in serum decreased gradually,even below the zero while the dose increased to1×10 5 mg /kg body weight,SOD activity decreased to340.40±63.18Nu/ml that was lower than control group (P<0.05),and the activity decreased by18.55%,which showed the SOD activity was inhibited.Therefore,the research on the dose-effect relationship is critical in the development of Chinese herbal medicine.

关 键 词： 中药复方制剂 延命散 超氧化物歧化酶 量效关系 酶活力升高率 药效学

领　　域： [农业科学] [农业科学] [农业科学]