作　　者： ; ; ; (肖儒坚）;

机构地区： 广东药科大学

出　　处： 《广东化工》 2016年第12期25-27,共3页

摘　　要： RAFT法合成兼具温度-pH双重敏感性嵌段共聚物。以嵌段共聚物为载体,吲哚美辛为模型药物,透析法制备载药胶束并模拟在人体环境中的药物释放,考察载体的释药性能;FT-IR表征嵌段共聚物及载药胶束;UV法测定聚合物LCST及相变pH,并进行载药胶束的体外释药研究。一系列测试表明载药胶束在人体生理温度(37℃)下,酸性环境的药物释放速率和累积释放量要比碱性环境下小很多。嵌段共聚物兼具温度-pH双重敏感性,可作为药物载体,在药物缓释控释方面有潜在的应用。 The block copolymers with temperature-pH sensitive were Synthesized via RAFT. Drug-loaded micelles were prepared by dialysis with block copolymer as a carrier and indomethacin as a model drug. Simulating the environment in human, drug release property was investigated. Block copolymers and micelles were characterized by FT-IR. The LCST and phase change pH of polymers and drug release of drug-loaded micelles in vitro were measured by UV. A series of tests showed that micelles at physiological temperature（37 ℃）, the drug release rate and cumulative release amount in acidic environment was much smaller than alkaline environment. The block copolymers had sensitivity of temperature and pH, which could be used as a drug carrier and had potential application in the controlled release of the drug.

关 键 词： 嵌段共聚物 温度 双重敏感性 吲哚美辛 药物释放

领　　域： [化学工程]