作　　者： ; ; ; ; ;

机构地区： 四川大学华西基础医学与法医学院

出　　处： 《中华医学遗传学杂志》 2002年第3期187-189,共3页

摘　　要： 目的　以中国北方汉族群体为基础制作 2 2号染色体 6个短串联重复序列 (short tandemrepeat,STR)连锁遗传图 ,比较 2 2号染色体物理距离与遗传距离的关系。方法　用 PCR方法对 6个 STR基因座进行分型及家系分析。结果　绘制出中国北方汉族群体 2 2号染色体 6个 STR的遗传图 ,初步比较了 2 2号染色体 6个 STR基因座间遗传距离与物理距离的关系。结论　 2 2号染色体上 6个 STR间的遗传距离与物理距离存在较复杂的关系 :6个 STR基因座的遗传距离不仅与物理距离的大小有关 ,而且中国人与白人以及性别之间 2 2号染色体物理距离与遗传距离的关系存在差异。 Objective: To construct a genetic map based on data from the Chinese population in northern part of China and to compare relationship between physical distance and genetic distance on chromosome 22. Methods: PCR amplification was employed to genotype 6 STR loci on chromosome 22, and pedigree analysis was performed. Results: A genetic map of Chinese Han population in the northern part of China was constructed and a preliminary comparison of the physical and genetic distances between 6 STR loci on chromosome 22 was made. Conclusion: There is complex relationship between genetic distance and physical distance: the distance between STR loci is related to physical distance but also recombination fraction, and there are differences of the genetic and physical distances on chromosome 22 between Chinese and Caucasian, and between the male and female.

关 键 词： 号染色本 遗传图 重组率 遗传距离 物理距离

领　　域： [生物学] [生物学]