机构地区: 中山大学化学与化学工程学院
出 处: 《食品科学》 2002年第5期51-54,共4页
摘 要: 本文研究了单酯化高甜度甜味剂-三氯蔗糖的合成。采用蔗糖与原乙酸三乙酯的反应保护蔗糖6-位羟基,亚硫酰氯/吡啶选择性氯化蔗糖6-乙酸酯制备三氯蔗糖。蔗糖6-乙酸酯的最佳氯化条件为:蔗糖6-乙酸酯浆状物20g,吡啶20ml,亚硫酰氯22~22ml,反应介质1,2-二氯乙烷,回流时间10~11h。其氯化产物采用甲醇-甲醇钠水解脱去6-位羟基得到三氯蔗糖。单酯化法较三苯甲基化法合成三氯蔗糖大大简化了操作过程,同时反应条件比较温和,也降低了对设备的要求。 Preparation of high intensity sweetener 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose by using monoesterification has been studied.The 6-position hydroxyl group in sucrose was protected by the reaction of sucrose with triethyl orthoacetate.Sucralose was prepared by chlorinated sucrose 6-acetate with thionyl chloride/pyridine.The optimum chlorination condition was:sucrose 6-acetate syrup(20g),Thionyl chloride(20~22ml),1,2-dichloroethane as reaction mediums and refluxed time was 10~11 hours.The chlorinated product was hydrolyzed with methanol-sodium methoxide to deacetylation.With the mono-esterification,the preparation route should be simple and the reaction condition was more gentle than with tritylation.