作　　者： ; ; ; (卞垒）; (罗创龙）;

机构地区： 暨南大学生命科学技术学院化学系

出　　处： 《有机化学》 2014年第5期994-998,共5页

摘　　要： 以咔唑为原料,经烷基化、甲酰化反应合成N-烃基咔唑-3-甲醛;无催化剂条件下,N-烃基咔唑-3-甲醛与邻苯二胺经缩合-环化"一锅"反应合成了两类新型含咔唑单元的苯并咪唑衍生物.研究了溶剂选择、溶剂用量、反应温度、反应物配比等因素对缩合-环化反应结果的影响;通过改变两种反应物的等物质的量比可选择性地得到以其中一类苯并咪唑衍生物为主的产物. Two series of novel benzoimidazole derivatives containing carbazole unit were synthesized via condensation-cyclization of N-alkylcarbazole-3-formaldehyde with 1,2-diaminobenzene in ＂one pot＂ reaction without catalyst. The effects of temperature, selection amount of solvents and molar ratio of the two reagents on the reactions have been investigated; significantly, one of these two series of benzoimidazole derivatives could be prepared as the major products selectively by changing the molar ratio of the two reagents.

关 键 词： 苯并咪唑 咔唑 有机合成

领　　域： [理学] [理学]