机构地区: 广州中医药大学中药学院
出 处: 《天然产物研究与开发》 2014年第2期193-196,共4页
摘 要: 采用多种层析方法从广东桑根心材的醇提取物中分离了8个已知化合物,经波谱分析手段结合文献分析方法将其分别鉴定为:桑辛素C(1),桑辛素M(2),二氢桑色素(3),氧化白藜芦醇(4),2,4-二羟基苯甲醛(5),伞形花内酯(6),胡萝卜苷(7)和3-羟基-2-哌啶酮(8)。化合物1,3~6和8首次从广东桑Morus atpropur-purea中分离,化合物8亦首次从桑属植物中分离。综合采用DPPH,MTT法测试了多酚类化合物1—4的抗氧化和神经保护作用,结果表明化合物1~4均能清除DPPH自由基,抑制L-谷氨酸钠诱导海马神经元细胞HT22毒性,具有抗氧化和神经保护作用。在20μM浓度下,化合物2的活性显著。 Eight known compounds, including Moracin C (1), Moracin M (2), Dihydromorin (3), Oxyresveratml (4), 2, 4-Dihydroxybenzaldehyde (5),7-Hydroxyeoumarin (6) , Daueosterol (7) and 3-Hydroxy-2-piperidinone ( 8 ) have been i- solated from EtOH extract of heartwood of root of Morus atpropurpurea. Compounds 1,3-11 and 8 were isolated from Morus atpropurpurea for the first time. Compound 8 was also isolated from Morus plant for the first time. Their antioxidant and neuroprotective activity were test by DPPH, MTT methods. Polyphenolic compounds 1-4 exhibited antioxidative and neu- roproteetive aetivitives. Compound 2 showed significant neuroproteetive activity at 20 μM.