作　　者： ; ;

机构地区： 华南理工大学轻工与食品学院

出　　处： 《中国食品添加剂》 2013年第4期158-164,共7页

摘　　要： 以间苯二酚与乙酰乙酸乙酯为原料,研究了以高氯酸作为催化剂,在常温下催化合成羟甲香豆素的合成工艺,探讨反应时间、催化剂用量和原料摩尔比3个单因素对羟甲香豆素产率的影响,并在单因素试验的基础上利用Box-Benhnken试验设计和响应面分析法得出羟甲香豆素合成的最佳工艺条件为:反应体系中间苯二酚的添加量为30mmol时,反应时间:5.3h,高氯酸添加量:21mL,乙酰乙酸乙酯与间苯二酚的摩尔比为1.1∶1,此条件下羟甲香豆素的产率可达93.19%。 The synthesis of hymecromone was studied with resorcinol and ethyl acetoacetate as raw material and perchloric acid as catalyst.Reaction time,the dosage of catalyst and the mole ratio of reactants were studied as single factors to determine the yield of hymecromone.The Box-Benhnken central composite test and response surface design were used to determine the optimal conditions.The experimental results showed that the best reaction parameters were： resorcinol 30mmol,reaction time 5.3h,Perchloric acid 21mL and the mole ratio of ethyl acetoacetate and resorcinol 1.1：1.Under the above conditions,the yield of hymecromone was 93.19%.

关 键 词： 羟甲香豆素 间苯二酚 乙酰乙酸乙酯 响应面分析

领　　域： [轻工技术与工程] [轻工技术与工程]