作　　者： ; ; ; ;

机构地区： 广东工贸职业技术学院机械工程系

出　　处： 《材料研究学报》 2013年第4期391-396,共6页

摘　　要： 以聚己内酯二醇为软段、赖氨酸二异氰酸乙酯为硬段和异山梨醇为扩链剂,用二步逐步聚合法合成了医用可降解的聚氨酯;采用相转变-粒子沥滤法制备聚氨酯多孔三维支架,并考察了支架的形貌,孔径大小、分布和支架的力学性能,用小鼠畸胎瘤细胞进行了支架的细胞增殖实验。结果表明,制备出的聚氨酯支架由大小不同的孔构成,孔隙率超过75%;其中添加不良溶剂甲醇和水制备得到的支架,孔与孔之间连通性较好,具有良好的抗压性能。细胞增殖测试结果表明,这种聚氨酯支架支持细胞的生长和增殖。 A two-step method was used to synthesize a novel biodegradable polyurethane （PU） com- posed by L-lysine ethyl ester diisocyanate （LDI）, poly （ε-caprolactone） diols （PCL-diol） and 1, 4： 3, 6-dian- hydro-D-sorbitol （Isosorbide） as chain extender. 3D porous PU scaffolds were produced by a combined salt leaching-phase inverse technique. The surface structure, pore size, pore size distribution, pore inter- connectivity and mechanical properties of the scaffolds were investigated. The bio-safety of PU was eval- uated with cell proliferation of mouse ATDC5. Results show that micorpores and macropores distributed in the produced scaffolds with high porosity （more than 75%）. The scaffolds that were prepared with addi- tion of methanol and water have good tensile strength, with well interconnected pores. In addition, the CCK-8 expriment result displayed that the cells could survive and proliferate on PU scaffolds.

关 键 词： 有机高分子材料 生物降解聚氨酯 支架 制备 相转变 粒子沥滤技术

领　　域： [一般工业技术]