作　　者： ; ; ; ; ; ; ;

机构地区： 南方医科大学南方医院

出　　处： 《核技术》 2013年第6期29-32,共4页

摘　　要： 回顾性分析147例行99mTc–DTPA肾动态显像的糖尿病患者,按照患病时间将观察对象分为病程小于5年、5–10年、大于10年三组,分别测定治疗前双肾GFR、血肌酐水平、24 h尿蛋白定量。选择22例肾移植供者为正常对照组,同时对不同时间段的以上指标进行统计学分析。结果显示,糖尿病患者双侧肾脏功能差别无统计学意义(P=0.536)。糖尿病患者双肾GFR与血肌酐水平存在明显相关关系(R2=0.762),24 h尿蛋白定量与双肾GFR或血肌酐不存在明显相关性。在患病早期、中期,双肾GFR、血肌酐之间差别有统计学意义(P<0.05);在肾功能损伤的中、晚期,双肾GFR、血肌酐之间差别无统计学意义(P值分别为0.781、0.297)。24 h尿蛋白定量在相邻两个患病阶段差别均无统计学意义。在评价肾功能早期损伤方面,双肾GFR较血肌酐更为敏感。结果表明,糖尿病患者双肾GFR与血肌酐水平存在明显相关关系,两者均可反映不同时期肾功能损伤程度,但双肾GFR比血肌酐能够更早发现糖尿病患者肾功能损伤;24 h尿蛋白定量不能单独评价肾功能的损伤程度。 Background： Diabetes nephropathy is a common complication of diabetes mellitus patients. Early detection of renal impairment can improve the quality of life of patients. Purpose： The value of total GFR, serum creatinine, 24-hour urine protein excretion in diabetes mellitus patients with renal impairment were evaluated. Methods： A retrospective analysis of 147 patients with diabetes undergoing routine renal dynamic imaging was undertaken. The cases were divided into three groups according to the illness duration： group 1 of not more than five years, group 2 of five to ten years, Gr.3： more than ten years. The 22 renal transplant donors were selected as the normal control group. The total GFR, serum creatinine and 24-hour urinary protein excretion of all patients were measured before the treatments, and the data were statistically analyzed. Results： There was no significant differences in renal function between the two kidneys of in the diabetes mellitus patients（P=-0.536）. Serum creatinine and total GFR had significant correlation （R2=0.762）, but no significant relationship between the 24-hour urine protein and the total GFR or serum creatinine. In the early and middle times of renal function impairment, the total GFR and serum creatinine have significant difference in different time periods（P〈0.05）. During the mid-late times of renal function impairment, total GFR and serum creatinine have no statistically significant differences （P value is 0.781, 0.297）. 24-hour urine protein quality had no statistical differences in each stage. However, the total GFR is more sensitive than the serum creatinine in evaluation of early impairing of renal function. Conclusions： There is significant correlation between serum creatinine and total GFR. Both of them can reflect the degree of diabetic renal injury, but the total GFR is more sensitive than serum creatinine in early degree. 24-hour urine protein quantitative can not evaluate the degree of impaired renal function alone.

关 键 词： 肾动态显像 糖尿病 肾功能 血肌酐 尿蛋白

领　　域： [核科学技术]