作　　者： ; ;

机构地区： 南京体育学院

出　　处： 《南京体育学院学报（自然科学版）》 2013年第2期156-160,共5页

摘　　要： 近年来,除了关注雌激素对骨质疏松的防治外,关于雌激素对脑部神经元的保护作用及其机制的研究较多,已证实雌激素对神经元有保护作用,且可缓解脑部缺血再灌注损伤的炎症反应;合理运动对神经元的保护作用也早已证实,且力竭运动可引起细胞凋亡及炎症反应等,这一点在中枢疲劳中也有体现,而PI3K/Akt通路与葡萄糖代谢,抑制细胞凋亡密切相关。将三者结合作一综述,期待为进一步探讨雌激素及运动对神经保护作用提供更多依据。 In recent years, an increasing amount of atten- tion has been given not only to the effect of estrogen on the prevention and treatment of osteoporosis, but also to the protective effect and mechanism of estrogen on brain neurons. It has been confirmed that estrogen has a protec- tive effect on neurons, and can ease the brain ischemiareperfusion injury inflammatory response. The protective effect of reasonable exercise on neurons has also long been verified. And exhaustive exercise can cause apoptosis and inflammatory response, which is also reflected in the central fatigue. Meanwhile, the PI3K/Akt pathway is closely related to glucose metabolism and the inhibition of apoptosis. This article will review the above three factors, with a view to providing a basis for further study on the effects of estrogen and exercise on the protective functions of neurons.

关 键 词： 雌激素 运动 通路

领　　域： [文化科学] [文化科学]