机构地区: 嘉应学院化学与环境学院
出 处: 《无机化学学报》 2013年第6期1222-1226,共5页
摘 要: 采取分步反应法以1R,2R-环己二胺(或1S,2S-环己二胺)与2-羟基萘甲醛和水杨酸苯酯反应,合成了一对手性Salen型席夫碱对映体:1R-(2-羟基苯甲酰亚胺)-2R-(2-羟基萘甲亚胺)环己烷(1a)和1S-(2-羟基苯甲酰亚胺)-2S-(2-羟基萘甲亚胺)环己烷(1b),对其进行了单晶结构、圆二色光谱、元素分析、红外光谱表征及生物活性实验。单晶结构与圆二色光谱分析表明1a和1b互为对映体;生物活性实验显示1a具有一定的抑菌活性。 Two chiral Salen-type Schiff base enantiomers, 1R-(2-hydroxy benzimine)-2R-(2-hydroxy naphthylmethylenimine) cyclohexane (1a) and 1S-(2-hydroxy benzimine)-2S-(2-hydroxy naphthylmethylenimine) cyclohexane (1b), synthesized though the solution reactions of phenyl salicylate, trans-1, 2-diaminocyclohexane and 2-hydroxynaphthalene-1-carbaldehyde in 2-propanol, have been characterized by EA, IR, X-ray crystallography, Circular Dichroism (CD) spectrum and biological tests. X-ray crystallography and CD spectrum reveal la and lb are optically chiral enantiomers. Biological tests show that la has inhibiting bacteria effects. CCDC: 932330, 1; 932331, 2.