作　　者： ; ; ; ; (王祝彬）; (吴益芳）;

机构地区： 广州中医药大学第一附属医院

出　　处： 《现代食品科技》 2013年第3期615-620,共6页

摘　　要： 按照保健食品安全性毒理学评价程序,采用急性毒性试验、遗传毒性试验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)和30 d喂养试验进行粉葛氨糖复方的安全性评价。结果粉葛氨糖复方对雌、雄昆明种小鼠的最大耐受剂量(MTD)均大于20.0 g/(kg.bw);三项遗传毒性试验(Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验)结果均为阴性;30 d喂养试验未见大鼠的生长发育、血液学、生化及组织病理学有异常变化。粉葛氨糖复方急性毒性分级属无毒级、无遗传毒性,在本实验剂量范围内,属安全性保健食品。 According to procedures for toxicological assessment of supplement food, acute toxicity test, genetic toxicity test （Ames test, micronucleus test ofbom marrow in mice, sperm shape abnormality test in mice） and thirty-day feeding test in rats were conducted to assess toxicological safety of mice and rats fed with Kduzu-glucosamine formula. The results showed that mouse oral LD50 was above 20.0 g/（kg·bw）. Ames test and micronucleus test of bone marrow cells and sperm shape abnormality test in mice were all negative. Rats after being fed Kduzu -glucosamine Formula for 30 d with three different doses groups grew well. Hematology and hematology biochemistry index were all normal. No abnormal symptoms were observed after gross anatomy. Kduzu-glucosamine formula belongs to the actual innocuous level and no-genetic toxicity, being used according to recommending amounts is safe.

关 键 词： 粉葛氨糖复方 急性毒性 遗传毒性 喂养试验 安全性 毒理学

领　　域： [农业科学] [农业科学]