作　　者： ; ; (廖雪玲）;

机构地区： 上海公谊兽药厂上海201401

出　　处： 《中国畜牧兽医》 2013年第1期199-203,共5页

摘　　要： 文章综述了抗菌药药动学/药效学(PK/PD)模型的发展,详细阐述新型药动物学/药效学模型在抑制细菌耐药突变上的作用,为合理用药及新药研发提供指导,并指出了临床应用所存在的问题。 Development history of pharmacokinetic/pharmacodynamic（PK/PD） model for antimicrobial drugs was reviewed in the present article,including the important role of new PK/PD model in inhibition bacterial resistance mutation,intruction in the rational design of drug regimen and new drug investigation.In addition,problems of clinical application of PK/PD model were also discussed.

关 键 词： 药动学 药效学模型 突变选择窗 耐药性 合理用药

领　　域： [农业科学] [农业科学] [农业科学]