作　　者： ; ; ; ; ; ;

机构地区： 广东出入境检验检疫局

出　　处： 《分析化学》 2013年第1期25-30,共6页

摘　　要： 建立了液相色谱-串联质谱法(LC-MS/MS)同时测定食品接触材料中28种初级芳香胺(PAAs)迁移量的方法。采用C3色谱柱,以甲醇-水为流动相,梯度洗脱分离,在电喷雾正离子模式下以多反应监测(MRM)方式检测,外标法定量。28种PAAs检出限(LOD,S/N=3)和定量限(LOQ,S/N=10)分别为0.02～0.3μg/kg和0.1～1.0μg/kg;在1.0～1000μg/L浓度范围内线性良好,相关系数大于0.9915;加标浓度在1.0～100μg/kg的回收率为77.8%～105.3%;相对标准偏差(RSD)为4.5%～11.8%。本方法操作简便、快速、准确、灵敏度高,能满足相关测定要求。 A method was developed for simultaneous determination of the migration of 28 kinds of primary aromatic amines（PAAs） from food contact materials by liquid chromatography-tandem mass spectrometry （LC- MS/MS）. The analytes were separated on a Ca column,eluted by gradient with methanol and water, identified by electrospray ionization mass spectrometry in positive mode using multiple reaction monitoring （MRM）, quantified by external standard method. The limits of detection （ LOD, S/N = 3 ） and quantification （ LOQ, S/N= 10） of 28 PAAs were 0.02-0.3 μg/kg and 0.1-1.0μg/kg, respectively. The correlation coefficients of linear calibration curve were over 0. 9915 in the ranges varied from 1.0 μg/L to 1000 μg/L. The recoveries of PAAs were 77.8% -105.3% in the spiked range of 1.0-100 μg/kg, and the relative standard deviation （RSD） was 4.5%-11.8%. The experiment results indicated that the method was simple, rapid, sensitive, accurate, and could meet the correlative requirements for determination.

关 键 词： 液相色谱 串联质谱 食品接触材料 初级芳香胺 迁移量

领　　域： [理学] [理学]