机构地区: 深圳市职业病防治院深圳518001
出 处: 《微生物与感染》 2012年第4期233-238,共6页
摘 要: 大肠埃希菌是引发尿路感染的主要病原体。流行病学调查显示,外膜蛋白酶T(OmpT)与尿路感染中大肠埃希菌的毒力相关。本文就OmpT的底物专一性、对宿主阳离子抗菌肽的抵抗,以及在纤溶系统和菌株黏附侵袭中的作用等方面的研究进展进行综述。 Uropathogenic Escherichia coli (UPEC) is the major cause of urinary tract infections worldwide. Outer membrane protease T (OmpT), as a putative uropathogenic virulence factor, is found more frequently in UPEC than in fecal isolates. This review covers the current progress on substrate specificity of OmpT, resistance to cationic antimicrobial peptides, roles in the fibrinolytic system and bacterial adhesion and invasion.
领 域: [生物学]