作　　者： ; ; ; ; ; ;

机构地区： 广东体育职业技术学院

出　　处： 《体育学刊》 2012年第6期132-138,共7页

摘　　要： 观察有氧运动联合谷氨酰胺(Gln)补充对2型糖尿病(T2DM)大鼠血清胰高血糖素样肽-1(GLP-1)、胰岛素(INS)及空腹血糖(FBG)水平的影响。将雄性SD大鼠60只((179.8±19.2)g)随机分为健康对照组(C组,26只)和糖尿病造模组(D组,34只)。C组普通饲料喂养,D组高脂喂养。4周后D组大鼠腹腔注射35 mg/kg链脲佐菌素(STZ)诱导T2DM。成模后两组大鼠进一步随机分为:安静组(CQ、DQ)、运动组(CE、DE)、Gln组(CG、DG)、运动加Gln组(CEG、DEG)。运动组大鼠进行6周游泳运动。Gln组改用质量分数为2%L-Gln饲料喂养。腹主动脉取血测FBG、胰岛素及GLP-1水平。结果:6周游泳运动或Gln补充,均明显提高D组大鼠GLP-1和胰岛素水平,显著降低FBG值,明显改善大鼠多饮多食症状,但对体重影响不明显。6周运动明显增加C组大鼠胰岛素水平,显著降低其FBG值,对GLP-1没有明显影响;6周的Gln补充明显降低C组大鼠的进食量,对FBG、胰岛素及GLP-1水平均无明显影响。当运动加Gln补充时,对D组大鼠FBG的控制、血浆GLP-1的增加、胰岛素水平的提高以及消耗症状的改善等均较运动或Gln补充单独作用时明显,但对体重的影响没有明显差异;二者联合对C组大鼠GLP-1的影响较运动或Gln补充单独作用时明显,但对FBG、胰岛素和体重的影响没有明显差异。结果表明:长期有氧运动或Gln补充可提高T2DM大鼠GLP-1水平,增加胰岛素分泌,降低血糖,改善多食多饮症状。当运动联合Gln补充时,降低T2DM大鼠血糖及升高GLP-1和胰岛素水平均较运动或Gln单因素作用明显。 In order to observe the effects of aerobic exercising combined with glutamine （Gln） supplement on the serum glucagon like peptide 1 （GLP-1）, insulin （INS） and fasting blood glucose （FBG） levels of rats with type 2 diabetes mellitus （T2DM）, the authors divided 60 male SD rats （（179.8＋19.2） g） randomly into a healthy control group （group C, 26 rats） and a diabetic model establishment ground （group D, 34 rats）. The rats in group C were fed with common feed, while the rats in group D were fed with high fat feed. 4 weeks later, the rats in group D were in- jected with 35 mg/kg of streptozotocin （STZ） to induce T2DM. After model formation, the rats in the two groups were further divided into calm groups （CQ, DQ）, exercising groups （CE, DE）, Gin groups （CG, DG） and exercising plus Gin groups （CEG~ DEG） randomly. The rats in the exercising groups did a 6-week swimming exercise. The rats in the Gln groups were fed with Gln a mass fraction of 2% L. Abdominal aorta blood was taken to test FBC1 insulin and GLP-1 levels. Results： 6-week swimming exercise or Gin supplement significantly increased the GLP-1 and insulin concentrations of the rats in group D, significantly decreased FBG value, significantly improved the symptom of polyphagia of the rats in group D, but had no significant effect on the body weight. 6-week exercising significantly increased the insulin level of the rats in group C, significantly decreased their FBG value, had no significant effect on GLP-1; 6-week Gin supplement significantly decreased the food intake of the rats in group C, had no significant effect on their FBG insulin and GLP-1 levels. When exercising was combined with Gln supplement, the control of FBG the increase of plasma GLP-1, the increase of insulin level and the improvement of consumption symptom of the rats in group D were more significant than those showed when exercising or Gin supplement worked separately, but there was no significant difference in the effect on the body wei

关 键 词： 运动生物化学 型糖尿病 有氧运动 谷氨酰胺 胰高血糖素样肽 胰岛素

领　　域： [文化科学] [文化科学]