作　　者： ; ; ; ; ; ;

机构地区： 华南理工大学轻工与食品学院

出　　处： 《华南理工大学学报（自然科学版）》 2012年第8期122-127,共6页

摘　　要： 采用超声法制备了右旋龙脑/羟丙基-β-环糊精包合物,并用差示扫描量热法和X-射线衍射法鉴定,然后采用气相色谱法,以右旋龙脑含量为指标,分别对包合物进行挥发性、热稳定性、抗光解性和相溶解度实验.结果表明:在常温、光和热的因素影响下,包合物中右旋龙脑的含量明显高于混合物,这表明包合物具有一定的抗光解性和热稳定性,其稳定性明显优于单纯的右旋龙脑,便于长久贮存而不改变疗效;羟丙基-β-环糊精浓度为0～8 mol/L时,右旋龙脑的浓度随着羟丙基-β-环糊精浓度的增加而增加,表明右旋龙脑形成包合物后,其溶解性得到了显著提高. Abstract： d-borneol/hydroxypropy-β-cyclodextrin （HP-β-CD） inclusion complex was prepared through ultrasound method, and was confirmed by means of the differential scanning calorimetry （ DSC ） and the X-ray diffraetometry （XRD）. Then, the volatility, thermal stability, anti-photodecomposition and phase solubility of the inclusion com- plex were tested with the d-borneol content as the index, which is determined via gas chromatography （GC）. The results show that, under the influence of light and heat at the room temperature, the content of d-borneol in the in- clusion complex is higher than that in the physical mixture of d-borneol and hydroxypropy-β-cyclodextrin, which in- dicates that the inclusion complex is of anti-photodissociation, thermal stability and a stability obviously superior to that of pure d-borneol, so it can be conveniently stored with the efficacy being preserved for a long time; and that the d-borneol concentration increases with the HP-β-CD concentration varying from 0 to 8 tool/L, which means that the solubility of d-borneol is significantly improved after the inclusion.

关 键 词： 右旋龙脑 羟丙基 环糊精 包合物 稳定性

领　　域： [轻工技术与工程] [轻工技术与工程]