作　　者： ; ; ; ; ; ;

机构地区： 海南大学材料与化工学院

出　　处： 《功能材料》 2012年第B08期101-104,共4页

摘　　要： 采用混酸氧化法制备表面带负电的羧基化碳纳米管分散体系,以叶酸靶向受体改性壳聚糖,通过羧基化碳纳米管与叶酸改性壳聚糖进行静电自组装,制备了生物相容性好、肿瘤靶向性高的碳纳米管/壳聚糖药物复合载体材料(FA/CS-SWCNTs)。利用FT-IR、XPS、SEM和TG等分析方法对相应产物的形貌和结构进行了研究。实验结果表明叶酸改性壳聚糖成功组装到羧基化碳纳米管上,热重分析显示该复合材料中壳聚糖的质量分数达到35%,其中叶酸在壳聚糖上的偶联率为8.1%,该载体材料具有良好的亲水性、安全性和靶向性等优点,有望成为新型的肿瘤靶向功能载体材料。 Carboxylated single walled carbon nanotubes were obtained by treat with mixed acid oxidation meth- od. Folic acid （FA） modified chitosan （CS） was prepared by the interaction between the amino group of CS and the EDC activated FA. And FA-CS/SWCNTs composites were self-assembled SWCNTs with folate FA-CS by electrostatic attraction. The resultant composites were biocompatible and can target delivery drug to cancer sites. The corresponding composites were characterized by FT-IR, XPS, SEM and TG analysis. The results showed that FA-CS/SWCNTs composites were successfully synthesized by self-assembly and the hydrophilic property, security and target activity was improved by the inducing of FA-CS molecular chain. TG analysis demonstrated that 35% of FA-CS was attached onto the surface of SWCNTs, and the FA to chitosan ratio was 8.1%. Because of the properties the FA-CS/SWCNTs composites have great potential to be used as targeted drug delivery carrier in the field of drug release areas.

关 键 词： 单壁碳纳米管 壳聚糖 叶酸 静电自组装

领　　域： [一般工业技术]