机构地区: 中国科学院成都生物研究所
出 处: 《合成化学》 2012年第3期389-392,共4页
摘 要: 采用简易方法从取代苯乙酮出发制得α-氟-β-脱氢氨基酸酯;在N,N-二甲基甲酰胺存在下用三氯硅烷将其还原,高收率和非对映选择性地合成了α-氟-β-氨基酸酯,其结构经1H NMR,13C NMR和MS确证。 α-Fluoro-β-amino esters in high yield with diastereoselectivity were synthesized using tri- chlorosilane as a reducer in the presence of DMF by a reduction of α-Fluoro-β-enamino esters which were prepared from aeetophenones by a simple method. The structures were confirmed by 1 H NMR, 13C NMR and MS.