作　　者： ; ; ; ; ;

机构地区： 广东石油化工学院

出　　处： 《精细石油化工》 2012年第2期28-30,共3页

摘　　要： 以噻吩、乙酸酐为原料,考察了不同催化剂对噻吩酰基化反应的影响;以中间产物2-乙酰噻吩(Ⅰ)为原料,研究了溶剂、相转移催化剂对中间产物氧化重排反应的影响。实验结果表明:负载型杂多酸H3PW12O40/SiO2为酰基化反应适宜催化剂。在氯仿为溶剂,适量聚乙二醇400作为相转移催化剂时,中间产物2-乙酰噻吩氧化重排生成2-噻吩乙酸甲酯(Ⅱ),(Ⅱ)经水解得产物2-噻吩乙酸(Ⅲ),经重结晶后产物产率可达66.8%。用1 H NMR,IR对产物结构进行了表征。 The influence of different catalysts on the acylation reaction of thiophene by using thiophene and acetic anhydride as the starting materials was reported.With 2-acetyl thiophene（Ⅰ） as the model substrate,the effect of solvents and phase-transfer catalysts on the oxidation rearrangement of the intermediate was studied.The results indicated that the oxidation rearrangement product 2-thienyl acetate（Ⅱ） was formed using H3PW12O40/SiO2 and PEG-400 as the co-catalysts in chloroform.Ⅱ was hydrolyzed to 2-thiophene acetic acid（Ⅲ） with the yield of 66.8% after recrystallization.The structure of Ⅲ was confirmed by 1H NMR and IR.

关 键 词： 负载型杂多酸 乙酰噻吩 噻吩乙酸甲酯 相转移催化剂 噻吩乙酸

领　　域： [化学工程]