作　　者： ; ; ; ;

机构地区： 广东外语艺术职业学院

出　　处： 《河南师范大学学报（自然科学版）》 2012年第2期140-143,共4页

摘　　要： 目的:探讨RES对大强度运动心肌过氧化损伤的保护作用.方法:在活动跑台上建立大强度运动模型,测试心肌各项过氧化损伤指标.结果:大强度运动可造成大鼠心肌MDA,TNOS,iNOS,NO显著升高,TSOD,CuZn-SOD,GSH-Px,cNOS,Na+,K+-ATPase,Ca2+-ATPase显著下降.补充RES可使大鼠运动后心肌MDA,TNOS,iNOS,NO下降,TSOD,CuZn-SOD,Mn-SOD,GSH-Px,cNOS,Na+,K+-ATPase,Ca2+-ATPase升高.结论:RES可增强心肌的抗氧化能力,保持心肌酶活性.提示RES对大强度运动后心肌过氧化损伤具有保护作用. Objective：To investigate the protective effects of resveratrol on exercise-induced myocardial damage in rats. Method：Mice were trained on intensive treadmill and indicators of myocardium were detected. Results：Activities of ALT, AST, CK, LDH, ALP in levels of myocardial MDA, total NOS,iNOS,NO increased significantly in rats after intensive exer- cise; while those of myocardial total SOD, CuZn-SOD, GSH-Px, cNOS, Na＋ K＋-ATPase, CaZ＋-ATPase decreased significantly in rats after intensive exercise. The supplement of resveratrol degraded activities of ALT, AST, CK, LDH, ALP in serum and levels of myocardial MDA, total NOS,iNOS,NO after intensive exercise; while raised those of myocardial total SOD, CuZn-SOD, GSH-Px, cNOS, Na^＋ K^＋-ATPase, Ca^＋-ATPase after intensive exercise. Conclusion：The study has demonstrated that resveratrol could enhance myocardial antioxygen and enzymatic activity which suggests the protective effects of resveratrol against exerciseqnduced myocardial damage in rats.

关 键 词： 白藜芦醇 大强度运动 一氧化氮 一氧化氮合酶 酶 心肌

领　　域： [文化科学] [文化科学]