作　　者： ; ; ;

机构地区： 怀化学院体育系

出　　处： 《南京体育学院学报（自然科学版）》 2012年第1期3-7,共5页

摘　　要： SIRT1(silent mating type information regulation 2 homolog1),哺乳动物sir2同系物,一种NAD+依赖的组蛋白脱乙酰化酶。越来越多的证据表明SIRT1通过其脱乙酰化酶活性参与糖脂代谢,其对胰岛β细胞功能和胰岛素信号通路起着正性调节作用,对改善胰岛素的敏感性和维持糖脂代谢稳态具有重要作用。运动疗法是防治2型糖尿病、非酒精性脂肪肝和动脉粥样硬化等慢性疾病主要方法之一,但运动改善慢性疾病的机理还未完全阐明。已有研究表明运动训练能够诱导大鼠骨骼肌和心肌组织中SIRT1表达。运动改善慢性疾病机理是否与SIRT1有关尚不确定。在总结SIRT1与糖脂代谢关系的基础上,结合运动与SIRT1的研究现状,展望SIRT1在运动医学领域的研究前景。 The silent mating type information regulation 2 homolog 1（SIRT1）,a mammalian sir2 homologue,is a NAD＋-dependent histone protein,deacetylase.More and more evidences show SIRT1 regulates glucose and lipid metabolism,islet β-cell function,INS/IGF-1 by its deacetylation.SIRT1 may plays an important role in the maintenance of steady-state glucose and lipid metabolism and insulin sensitivity.Movement therapy is one of the main methods in prevention and treatment of metabolic syndrome,such as type 2 diabetes,non-alcoholic fatty liverand atherosclerosis.The mechanism about movement to improve metabolic syndrome is not fully clarified.Existing researchs shows that exercise training can induce SIRT1 expression in skeletal muscle and heart tissues,but we can not determine whether the movement to improve the metabolic syndrome is still related to SIRT1.In this paper,we sumed up the relationship between SIRT1 and the glucose and lipid metabolism and based on the present research situation of SIRT1 and exercise and look forward to he research about SIRT1 in the field of sports medicine.

关 键 词： 糖代谢 脂代谢 胰岛素敏感性

领　　域： [文化科学] [文化科学]