作　　者： ; ; ; ;

机构地区： 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室

出　　处： 《畜牧兽医学报》 2012年第1期7-13,共7页

摘　　要： 近年来,蛋白酶体的分子组成、亚基、生化机理、胞内功能等方面的研究受到广泛关注,发展迅速。蛋白酶体的主要生物学功能包括:降解细胞内蛋白质、调节细胞周期、促进细胞凋亡、调节转录因子、增加抗原提呈等。在寄生虫中,蛋白酶体不仅参与胞内寄生虫的生长发育调节,同时对宿主造成损伤,并可诱导宿主产生对其的免疫应答。对寄生虫蛋白酶体的研究有助于深入了解寄生虫的入侵机制,为寄生虫病的防治提供新思路。作者对蛋白酶体的结构、功能及寄生虫蛋白酶体的研究进展作一综述。 Major advances have been achieved recently in the molecular composition of the proteasomes, their subunits, biochemical mechanisms and intracellular functions. Many cellular functions and processes are conserved in proteasomes including proteolytic functions, the regulation of cell cycle, apoptosis and transcription factor, enhancement of antigen presentation. In parasites, the proteasome is involved in the regulation of cell differentiation and replication, participation in impairment on hosts, and could therefore be an antigen inducing immune response in the host. Studies on parasite proteasomes will be beneficial for better understanding of mechanisms in host cell invasion by parasites, also providing a new thread for prevention and control of parasites. Therefore, this article reviews recent progress concerning the structure and functions of proteasomes, in particular, the parasite proteasomes.

关 键 词： 蛋白酶体 寄生虫 生物功能

领　　域： [农业科学] [农业科学] [农业科学]