作　　者： ; ; ; ; ; ; ; ; (张哲）; (邓刚）; (陈欢）;

机构地区： 浙江大学

出　　处： 《中国细胞生物学学报》 2011年第12期1374-1385,共12页

摘　　要： 异嗜性鼠白血病病毒相关病毒(xenotropic murine leukemia virus-related virus,XMRV)是迄今发现的第一种可以感染人类的r逆转录病毒。XMRV最初于2006年在RNase L基因缺陷型的前列腺癌组织中首次被鉴定,其序列与鼠科白血病病毒(murine leukemia virus,MLV)十分相似。目前,北美、欧洲和亚洲的多个研究机构在人类前列腺癌和慢性疲劳综合征(chronic fatigue syndrome,CFS)患者中检测到XMRV。但不同研究间结果差异很大,XMRV感染与人类疾病之间的相关性尚不明确。该文综述了目前XMRV的相关研究进展,包括与人类疾病的关系、XMRV的基本特征、病理生理学可能的机制等方面,并就今后研究趋势和注意问题进行了讨论。 Xenotropic murine leukemia virus-related virus （XMRV） is a new gammaretrovirus that can infect humans. Retroviruses are enveloped, positive-sense RNA viruses that are associated with many diseases, such as neoplasias, immunodeficiencies, and neurological disorders. XMRV was originally identified in prostate cancer patients with a deficiency in the antiviral enzyme RNase L in 2006. The genome of XMRV is closely related to xenotropic murine leukemia virus （MLV）. Recently, several independent groups have detected XMRV in prostate cancer and chronic fatigue syndrome patients, but the results vary greatly. The link between XMRV and human diseases has not been established. This paper presents and summarizes in detail the characteristics of XMRV, asso- ciation of XMRV with human diseases, and potential mechanisms of XMRV pathophysiology. We also discuss the future research direction, such as the establishment of standard operation procedure and epidemiologic evidence of an association of XMRV with human diseases in large-scale studies.

关 键 词： 异嗜性鼠白血病病毒相关病毒 逆转录病毒 前列腺癌 慢性疲劳综合征 致病机制

领　　域： [生物学]