作　　者： ; ; ; ;

机构地区： 广东药学院医药化工学院

出　　处： 《化学通报》 2011年第7期633-638,共6页

摘　　要： 合成和表征了一系列具有不同位阻和电子效应取代基的脒基配体。研究表明,脒基配体在有氧条件下,与氯化钯原位作用能有效地催化不同溴代反应物与苯硼酸的Suzuki偶联反应。考察了配体结构、反应温度和溶剂对反应的影响,结果表明,脒基配体上具有大体积和推电子取代基有利于偶联反应的进行;提高反应温度和引入质子性极性溶剂也是提高偶联反应产率的有效途径。 A series of amidinate ligands with different steric and electronic substituents were synthesized and characterized.Combination of amidinates with PdCl2 in situ furnished excellent catalyst precusors for the Suzuki coupling of various brominated substrates with phenylboronic acid under aerobic condition.The effects of varying ligand structure,temperature,and solvent on the performance of the coupling reaction were investigated.The results showed that the ligand with bulky and electron-donating group was more efficient.Besides,the optimization experiments revealed that the improvement of temperature as well as the polarity of the proton solvent turned out to be the effective method for the coupling reaction.

关 键 词： 脒基配体 氯化钯 偶联反应 溴代物

领　　域： [理学] [理学]