作　　者： ; ;

机构地区： 华南师范大学

出　　处： 《华南师范大学学报（自然科学版）》 2011年第2期1-6,共6页

摘　　要： 功能内稳态(FSH)用负反馈的方式维持功能特异的涨落,实现功能充分稳定的发挥.FSH特异的应激因子(FSSR)打破FSH.FSH特异的应激(FSH-specific stress,FSS)是系统对FSSR的响应,也可以处于FSS特异的内稳态(FSS-specific homeostasis,FSSH).处于FSSH的FSS打破FSH1,建立FSH2,称为成功应激.Sirtuin 1(SIRT1)是烟酰胺腺嘌呤二核苷酸辅酶(nicotinamide adenine dinucleotide,NAD+)依赖的组蛋白去乙酰化酶.人体存在FSH/FSSH特异的SIRT1活性.FSS可增加SIRT1活性.一个人可以同时有多种FSH,{FSHi,i=1,2,…,n}.每个FSH具有一个品质Q,{Qi,i=1,2,…,n}.定义Qmax=max{Qi,i=1,2,…,n},相应的功能记为Fmax.最佳品质结构是金字塔形,Qmax处于塔顶,只要Fmax可以获得最佳发挥,其它品质越小越好. Function -specific homeostasis （FSH） is a negative -feedback response of a biosystem to maintain the function- specific fluctuations inside the biosystem so that the function is perfectly performed. A stress is also a function of a biosystem. A FSH - specific stressor（FSSR） is so defined that it disrupts the FSH. A FSH - specific stress （FSS） of a biosystem is defined to be a response of the biosystem to a FSSR and may also be in FSS - specific homeostasis（FSSH） in which a FSS disrupt FSH1 but establish FSH2 so that it is called successful stress. There is FSH/FSSH - specific sirtuin 1 （ SIRT1 ） activity （ FSSA1 ）. SIRT1 is nicotinamide adenine dinucleotide （ NAD ＋ ） dependent, but NAD ＋ is limited by nutrition. A FSS increases SIRT1 activity so that FSSA1 is locally minimum. A person might simultaneously have many kinds of FSH, { FSHi, i = 1,2, …, n} , each of which has quality Q, { Qi ,i = 1,2,..., n } . Let Qmax = max { Qi,i = 1,2,..., n } and the corresponding function is Fmax,. The best structure of Q is a pyramidal hierarchy in which Qmax is at its peak but the other Q, are as low as possible if Fmax can be optimized.

关 键 词： 内稳态 应激 组蛋白去乙酰化酶 烟酰胺腺嘌呤二核苷酸辅酶

领　　域： [生物学]