作　　者： ; ; ; ; (谭宁锋）;

机构地区： 福建中医药大学

出　　处： 《中华中医药学刊》 2011年第4期837-839,共3页

摘　　要： 目的:观察心水通胶囊(XST)对慢性心力衰竭(CHF)患者利尿剂抵抗的临床治疗效果。方法:将74例被诊为CHF伴利尿剂抵抗患者随机分为治疗组38例和对照组34例。两组均采用常规西药治疗,治疗组在此基础上加服XST,每次3粒,每日3次,7天为一疗程,共观察两个疗程。在第7天和第14天分别对两组的心功能分级、左室射血分数、血清电介质、肝肾功能,以及日尿量、呼吸困难、体重、心率和血压等进行评价。结果:第1个疗程治疗组在尿量、呼吸困难和心功能改善效率分别为61%、33%和36%,明显优于对照组28%、19%和17%(P<0.05)。综合两个疗程计量指标发现,XST在有效利尿的同时,能明显改善左室射血分数、心率及体重(P<0.05),对肝肾功能及水电介质未发现不良影响,也未发现不良反应。结论:XST对CHF利尿剂抵抗患者具有明显的利尿作用,能改善CHF患者的心功能和症状,不良反应少,值得进一步深入研究。 Objective： Evaluate the effects of Xinshuitong Capsule（XST） on chronic heart failure（CHF） in patients with diuretic resistance.Methods and Results： 74 CHF patients with diuretic resistance were randomized into treatment group（TG,n=38） and control group（CG,n= 34）.Both groups were treated with conventional western medicine for CHF,while TG added XST（3 capsules po.tid） with 7 days for a course,two courses were observed altogether.At day 7 or 14,cardiac function,left ventricular ejection fraction,serum dielectric,liver and kidney functions,and the volume of urine output,dyspnoea,bodyweight,heart rate and blood pressure were evaluated.Results： In TG at course 1,urine output,dyspnoea and heart function improved significantly（61%,33% and 36%,respectively） than the control group（28%,19% and 17%）（P0.05）.Averaged the data from two courses,in addition to improve urine output,XST was effective in improvement the left ventricular ejection fraction,heart rate and body weight（P 0.05）,while no adverse effects of hepatic/renal functions,serum dielectric and no other side effects were found in the experiments.Conclusion： XST was effective on CHF patients with diuretic resistance and improved cardiac functions and symptoms with little adverse reactions,which was worthy of further study.

关 键 词： 心水通胶囊 慢性心力衰竭 利尿剂抵抗

领　　域： [历史地理] [历史地理]