机构地区: 中山大学
出 处: 《国际口腔医学杂志》 2011年第2期214-217,共4页
摘 要: 将自胚胎干细胞中筛选出的oct-4、sox-2、c-myc、klf-4四种基因组合转入体细胞,可获得与胚胎干细胞类似的诱导性多能干细胞。牙髓干细胞取材简单,尝试利用特异性多能转录因子将其重编程为与胚胎干细胞类似的诱导性多能干细胞,可为牙组织工程提供优质的种子细胞。本文就特异性多能转录因子的结构和功能、在体细胞去分化中的作用、在肿瘤发生中的作用、在牙髓细胞中的表达及其意义等作一综述。 Viral introduction of four genes(oct-4,sox-2,c-myc,klf-4) in committed somatic cells is sufficient to yield induced pluripotent stem(iPS) cells that resemble embryonic stem cells.Since dental pulp stem cell(DPSC) can be easily obtained from extracted teeth,attempts to reprogram DPSC to iPS cells by defined pluripotent transcription factors may provide a more advantageous seed cell source for tooth regeneration.This review mainly covers the structures and function of the defined pluripotent transcription factors,the roles they play in de-differentiation of somatic cell and in tumor genesis,and their expressions and significances in dental pulp cell.
领 域: [生物学]