作　　者： ; ; ; ; ;

机构地区： 山东大学医学院

出　　处： 《环境与健康杂志》 2011年第1期44-46,共3页

摘　　要： 目的研究隔膜型(membrane obstruction of inferior vena cava,MOIVC)布加综合征(Budd-Chiari syndrome,BCS)患者饮用水中碘浓度与凝血能力的关系。方法收集自2002—2008年间菏泽地区301例隔膜型布加综合征患者。分别于在2008年5月和2009年5月,测定饮水中铝(Al)等16种金属元素浓度和碘浓度。将隔膜型布加综合征患者按水碘浓度分为低水碘(<150μg/L)组、中水碘(150～300μg/L)组和高水碘(>300μg/L)组,并设一正常对照组,每组20人,男女各半。测定凝血酶原时间(PT-time)、凝血酶原时间国际标准化比值(PT-INR)、活化部分凝血酶原时间(APTT-time)、纤维蛋白原时间(Fbg-time)、纤维蛋白原浓度(Fbg-c)、凝血酶时间(TT)、抗凝血酶Ⅲ活力(AT-Ⅲ:A)和DD二聚体(DD-dimer)。结果饮水中所测金属元素均在正常值范围内。有89.37%(269/301)患者分布在高碘(水碘值>150μg/L)地区,32例患者分布在水碘值为12.63～150μg/L的地区。与正常对照组比较,水碘<150μg/L组隔膜型布加综合征患者凝血酶原时间、凝血酶原时间国际标准化比值、纤维蛋白原时间、纤维蛋白原浓度、活化部分凝血酶原时间和凝血酶时间均下降,差异有统计学意义(P<0.05或P<0.01);水碘>150μg/L的两组隔膜型布加综合征患者凝血酶原时间、凝血酶原时间国际标准化比值、活化部分凝血酶原时间、纤维蛋白原时间、凝血酶时间、抗凝血酶Ⅲ活力均升高,纤维蛋白原浓度下降,差异均有统计学意义(P<0.05或P<0.01)。各组DD水平间比较,差异无统计学意义。结论饮用水高碘与隔膜型布加综合征的分布有关,水碘与布加综合征患者凝血功能有关。 Objective To observe the relation of iodine content in drinking water and the coagulation function in membrane obstruction of inferior vena cava in Budd-Chiarri syndrome （BCS）. Methods Three hundred and one cases of BCS were chosen from 2002 to 2008, whose addresses could be found in Heze of Shandong province in China. Sixteen routine elements and iodine in drinking water were determined in May 2008 and May 2009. The patients were randomly divided into 3 groups based on the iodine content in drinking water： 〈150 μg/L group,n=20; 150-300μg/L group,n=20; 〉300μg/L group,n=20,and 20 healthy people were chosen as the normal control group, 10 women and 10 men in each group. The blood coagulation indexes, PT-time, PT-INR, APTT,Tr,Fbg-time,Fbg-C,AT3：A and D-dimer, were determined by Sysmex CA7000 automated blood coagulation analyzer. Results The metal elements in the drinking water were at normal levels. Two hundred and sixty-nine cases （89.37%） were found in high iodine areas （〉150μg/L）;32 cases were found in the areas where iodine content was 12.63-150μg/L. PT,PT-INR,Fbg- time, TT, APTT, Fbg-C decreased significantly in 〈 150μg/L group compares with the group （P〈0.05 or P〈0.01 ）. PT-time, PT- INR, Fbg-time,Tr, APTT increased significantly and Fbg-C decreased significantly in 150-300 μg/L and 〉300 μg/L group compared with the normal control group （except Fbg-time,P〈0.05 or P〈0.01）. Conclusion The high level iodine in drinking water is related to the case distribution of MOIVC of BCS. Iodine level in drinking water is related to the coagulation function of BCS patients.

关 键 词： 饮水 碘 布加综合征 下腔静脉隔膜阻塞 凝血

领　　域： [理学] [理学]