作　　者： ; ; ; ;

机构地区： 中山大学生命科学学院

出　　处： 《中山大学学报（自然科学版）》 2010年第6期83-88,共6页

摘　　要： 利用支持向量机(SVM)技术构建Par-4关联的蛋白质相互作用网络,预测出与Par-4有相互作用的蛋白质82个;这些蛋白质按照功能划分为8大类,主要包括:蛋白激酶、泛素化蛋白酶、死亡受体相关因子、与细胞周期或DNA复制相关蛋白质、调节蛋白质、与疾病相关蛋白质、具有特定结构域结合蛋白质和其他蛋白质等。结合文献挖掘和数据库检索信息,推断出了Par-4的2条可能新的信号转导途径。首次预测到Par-4与一大类泛素化蛋白有密切的关系。研究发现,Par-4与多种蛋白质具有复杂的相互作用,并且,在多个细胞凋亡途径中扮演了重要角色。 Based on the Support Vector Machine algorithm,the protein-protein interactions（PPI） networks between Par-4,the cancer-related apoptosis protein,and related proteins have been built.There are 82 proteins have been predicted interacting with Par-4.The proteins are classified into eight groups by biological functions,which include protein kinase,death receptor associate factor,ubiquitin-protein ligase,special disease associate proteins,DNA replication related proteins,special structure associate protein,regulatory protein and others.Combined with literatures mining and molecular chaperones of Par-4 searching from BOND database,two new signal transduction pathways of Par-4 have been deduced.In this paper,we first discover that Par-4 interacts with a group of ubiquitin-proteins.We find that Par-4 has complicated interactions with many proteins.Par-4 plays a major role in some apoptosis pathways.

关 键 词： 蛋白质相互作用 细胞凋亡 信号转导

领　　域： [生物学]