作　　者： ; ; ; ; ;

机构地区： 广东工业大学轻工化工学院

出　　处： 《精细化工》 2010年第8期796-799,共4页

摘　　要： 以2-氯噻吩、多聚甲醛为原料,以离子液体[C2mim]Br、[C3mim]Br、[C4mim]Br、[C5mim]Br、[C6mim]Br、[C7mim]Br、[C8mim]Br、[C12mim]Br、[Bmim]PF6、[Bmim]BF4、[Bmim]C4F9SO3和[Bmim]Cl为催化剂进行氯甲基化反应,得到产物2-氯-3-氯甲基噻吩。研究表明,离子液体可以促进2-氯噻吩的氯甲基化反应,具有相转移催化剂的效果,并且以[C4mim]Br和[C8mim]Br的催化效果为佳。反应最佳条件为:离子液体[C8mim]Br摩尔分数为5%(相对于2-氯噻吩),温度40℃,反应时间8h,产物产率可达92.1%。 The chloromethylation of 2-chloro-thiophene and paraformaldehyde to 2-chloro-3-chloromethyl-thiophene in the catalysis of different ionic liquids,[C2mim]Br,[C3mim]Br,[C4mim]Br,[C5mim]Br,[C6mim]Br,[C7mim]Br,[C8mim]Br,[C12mim]Br,[Bmim]PF6,[Bmim]BF4,[Bmim]C4F9SO3 and [Bmim]Cl was investigated.Result showed that as a phase transfer catalyst ionic liquid could promote the chloromethylation of 2-chloro-thiophene.[C4mim]Br and [C8mim]Br had the best catalytic activity.The influence factors,such as the dosage of catalyst,reaction temperature,reaction time and the amount of paraformaldehyde were discussed.Under the best conditions,the dosage of catalyst [C8mim]Br was 5%,40 ℃,8 h,a good yield was obtained in 92.1%.

关 键 词： 离子液体 氯噻吩 氯 氯甲基噻吩 氯甲基化 医药与日化原料

领　　域： [化学工程] [理学] [理学]