作　　者： ; ; ; ; ; ;

机构地区： 佛山科学技术学院农牧学院

出　　处： 《华中农业大学学报》 2010年第4期484-488,共5页

摘　　要： 从试验动物心率、心肌酶谱、心电图以及心脏病理学变化等方面研究麻黄对心脏可能的毒性作用。将青年健康新西兰大白兔56只随机分为4组,分别以20.0 g/kg(高剂量组)、10.0 g/kg(中剂量组)、2.0 g/kg(低剂量组)麻黄煎剂和蒸馏水10.0 g/kg(空白对照组)灌胃,连续7 d,测定试验前后心率、心电图,试验结束后采集血液和心肌组织测试心肌酶谱,观察心脏病理变化。结果发现:麻黄高、中剂量可显著减缓心率;心肌酶谱出现以活性显著增高为主的紊乱变化;心电图波形异常,P波、R波群振幅增大,PR间期延长,中剂量/高剂量分别延长/缩短QT间期;心脏组织结构造成损伤,损伤累及全心。试验结果初步表明,麻黄对试验动物心脏功能和结构造成明显损伤,而且损伤在一定范围内呈现剂量累积效应。 Possible cardiotoxicity of ephedra to test animal was investigated in variation of pulse,myocardial enzyme spectrum,electrocardiogram and pathologic histology.Fifty-six rabbits were divided into 4 groups randomly with intra-gastric administration of 20.0 g/kg body weight（high dosage）,10.0 g/kg body weight（middle dosage）,2.0 g/kg body weight（low dosage） concentrated extracts of ephedra,and 10.0 g/kg body weight distilled water（CK）,respectively.Ephedra solution was administrated for 7 d continually.Pulse（P） and electrocardiogram were measured pre and post ephedra treatment.Blood and myocardium tissues were sampled to assay myocardial enzyme spectrum.Pathologic changes of heart were observed post ephedra treatment.The results showed that pulse slowed down significantly in rabbits treated with high dosage and middle dosage of ephedra.Myocardial enzyme spectrum was in disorder expressed predominately by the significant increase of the enzyme activities.Cardiogram showed abnormality with enhanced amplitudes of P wave and R complex,and increased PR interval.Both high dosage and middle dosage prolonged/reduced QT interval.Damage occurred in myocardial tissue structure as well as the whole heart after ephedra treatment.The results indicated that ephedra affected the heart functions and damaged myocardial tissue structure apparently with dose dependent manner to a certain extent.

关 键 词： 麻黄 心脏毒性 心肌酶谱 心电图 病理组织学 家兔

领　　域： [农业科学] [农业科学]