作　　者： ; ; ; ;

机构地区： 湖南大学化学化工学院

出　　处： 《有机化学》 2010年第6期923-927,共5页

摘　　要： 以履代(口片)吶酮,经1,2,4-三唑取以、溴以、硫脲环合得到4-叔丁基-5-(1,2,4-三唑-1-基)-2-氨基噻唑;再与芳醛缩合合成一系列新4-叔丁基-5-(1,2,4-三唑-1-基)-2-苄亚氨基噻唑(5).用单晶X射线衍射测定了化合物5a的晶体结构.化合物5a的晶体属三斜晶系,空间群以P-1,晶胞参数以:a=0.72749(12)nm,b=0.93463(15)nm,c=1.3398(2)nm,α=70.185(2)°,β=75.669(2)°,γ=73.611(2)°;V=0.8105(2)nm3,Z=2,Dc=1.342g/cm3,F(000)=344,R1=0.0431,wR2=0.1611,S=1.01.生物活性实验结果表明:化合物5c(25mg/L)对小麦赤霉病菌、稻曲病菌、对黄瓜灰霉病菌和稻纹枯病菌的抑制率分别以100%,100%,82.8%和80.3%.化合物5d(25mg/L)对稻纹枯病菌、油菜菌核病菌、小麦赤霉病菌和稻曲病菌的抑制率分别以100%,95.5%,100%和100%.化合物5e(25mg/L)对小麦赤霉病菌的抑制率以100%.5d对小麦赤霉病菌、油菜菌核病菌和水稻纹枯病菌的EC50值分别以1.16,1.38和1.47mg/L. A novel series of（E）-N-benzylidene-4-tert-butyl-5-（1,2,4-triazol-1-yl）thiazol-2-amines have been designed and synthesized by reaction 4-tert-butyl-5-（1,2,4-triazol-1-yl）thiazol-2-amine with substituted aromatic aldehydes.Their structures were clearly established by MS,1H NMR techniques.The crystal structure of compound 5a has been determined by X-ray diffraction analysis.The compound 5a crystal belongs to triclinic system with space group P-1 and cell parameters：a=0.72749（12） nm,b=0.93463（15） nm,c=1.3398（2） nm,α=70.185（2）°,β=75.669（2） °,γ=73.611（2）°;V=0.8105（2） nm^3,Z=2,Dc=1.342 g/cm^3,F（000）=344,R1=0.0431,wR2=0.1611,S=1.01.The preliminary bioassays indicated that compound 5c exhibited 100%,100%,82.8% and 80.3% inhibition rate against G.zeae,U.virens,B.cinerea and R.solani at 25 mg/L.The compound 5d exhibited 100%,95.5%,100% and 100% inhibition rate against R.solani,S.scerotirum,G.zeae and U.virens at 25 mg/L.The compound 5e exhibited 100% inhibition rate against G.zeae.EC50 values of 5d were 1.16,1.38 and 1.47 mg/L against G.zeae,S.scerotirum and R.solani,respectively.

关 键 词： 叔丁基 三唑 基 苄亚氨基噻唑 合成 杀菌活性 晶体结构

领　　域： [农业科学] [农业科学] [农业科学]