作　　者： ; ; ; ; ;

机构地区： 大连理工大学汽车工程学院工业装备结构分析国家重点实验室

出　　处： 《功能材料》 2010年第4期656-658,共3页

摘　　要： 以直接熔融缩聚方法成功地制备了L-乳酸和α-丙氨酸聚酯酰胺共聚物,采用红外光谱、核磁共振、凝胶色谱、示差扫描量热仪和X射线衍射等方法对共聚物结构进行了分析表征,重点考察了投料比对产物组成、分子量及其热性能和结晶性能的影响,并对共聚物的降解性能进行了初步试验。随着α-丙氨酸含量的增加,相应共聚物的分子量明显下降,结晶性能下降直至变成无定形态。降解速率受共聚组分α-丙氨酸含量的控制,随之增加而加快,结果表明所制备的L-乳酸和α-丙氨酸聚酯酰胺共聚物具有良好的降解性能,是一种良好的药物缓释载体材料。 Poly （L-lactic acid-co-α-alanine） copolymer,as one of biodegradable poly（ester-amide）s derived from L-lactic acid and α-alanine,was synthesized by direct melting copolymerization with stannous chloride and p-toluenesulfonic acid as catalyst system.The structure and properties of the obtained copolymers were measured via FT-IR,13CNMR,GPC,DSC and XRD.With increasing of the content of α-alanine in feed,the data of copolymer molecular weight decreases,the diffraction and the melting peak disappear markedly.The hydrolytic degradation test indicated the resulting copolymer has an excellent degradability;its degradation rate could be enhanced by incorporating more α-phenylalanine into copolymer chain.It is suggested that the obtained copolymer is a potential biomedical material as drug coating on cardiovascular stent.

关 键 词： 聚 乳酸 聚酯酰胺 丙氨酸 熔融缩聚 生物可降解

领　　域： [理学] [理学]