机构地区: 湘南学院化学与生命科学系
出 处: 《应用化学》 2010年第4期494-496,共3页
摘 要: 以2-甲硫基苯胺为原料,通过酰化、碘环化以及Suzuki交叉偶联反应,合成了5-甲基-2,3-二苯基-1,5-苯并硫氮杂卓-4(5H)-酮。分别考察了催化剂对酰化反应、溶剂对碘环化反应的影响,以及催化剂、配体、碱和温度等因素对Suzuki交叉偶联反应的影响,在最佳的反应条件下,反应总收率为68.5%,中间产物和目标产物的结构经IR、NMR和MS等测试技术得以确证。 5-Methyl-2,3-diphenyl-1,5-benzothiazepin-4(5H)-one was synthesized via the acylation reaction and iodocyclization reaction and Suzuki cross-coupling reaction with 2-(methylthio)aniline as the initial material.Effects including catalysts on acylation reaction,solvents on iodocyclization and catalysts,ligand,base and reaction temperature on Suzuki cross-coupling reaction have been investigated.Under optimum conditions,the yield of the product was up to 68.5%.The chemical structures of the intermediates and target product were characterized by IR,NMR and MS spectra.
关 键 词: 甲基二苯基苯并硫氮杂卓 酮 酰化反应 碘环化反应 交叉偶联反应