作　　者： ; ; ;

机构地区： 华南师范大学体育科学学院

出　　处： 《体育学刊》 2010年第3期92-98,共7页

摘　　要： 综述了线粒体的结构功能及心肌细胞凋亡过程与线粒体的密切关系,探讨其参与运动诱导心肌细胞凋亡的可能机制。线粒体在心肌细胞凋亡中起关键的作用,细胞凋亡过程中许多重要事件的发生都与线粒体密切相关,包括线粒体通透转变孔道(mPTP)的开放、线粒体膜电位(?Ψm)的丧失、线粒体内外膜间隙促凋亡蛋白的释放、细胞内氧化还原状态的改变、Ca2+超载、Bcl-2家族促进和抑制凋亡蛋白的参与等。 More and more evidence indicated that mitochondria play the key role in cadiocyte apoptosis. Many events happened in apoptotic process have been tightly related to mitochondria, including mitochondrial permeability transition pore（MPTP） open, the depletion of mitochondrial membrane potential （mitochondrial △ψm）, mitochondrial intermembrane space pro-apoptotic protein release, alteration of redox state, Ca^2＋ overloading, participa- tion of Bcl-2 family and so on. The mitochondrial structure and function and its tight relation to apoptosis were reviewed, the possible mechanism of mitochondria on cadiocyte apoptosis induced by exercise were also summarized in the article.

关 键 词： 运动医学 线粒体通透转变孔道 线粒体膜间隙 运动 心肌 细胞凋亡 综述

领　　域： [文化科学] [文化科学]