作　　者： ; ; ; ; ; ; ;

机构地区： 河南农业大学牧医工程学院

出　　处： 《江西农业大学学报》 2010年第1期119-122,共4页

摘　　要： 根据耐酶抑制剂β-内酰胺酶(IRBLs)的耐药表型特点,应用纸片扩散法(K-B法)检测40株鸭大肠杆菌产IRBLs情况并分析产IRBLs菌的耐药性。结果表明:产IRBLs阳性株4株,阳性率为10%,其对阿莫西林、阿莫西林/棒酸、氨苄西林、氨苄西林/舒巴坦、替卡西林/棒酸、氟苯尼考、庆大霉素、新霉素、多西环素耐药,说明IRBLs产生菌已在我国兽医临床上出现,且呈现多重耐药的特点。此外,2株产IRBLs菌对哌拉西林/三唑巴坦敏感,表明三唑巴坦对哌拉西林有一定的保护作用。再者,1株产IRBLs菌对三代头孢耐药,该菌株可能同时产生超广谱β-内酰胺酶(ESBLs)或AmpC酶,这提示IRBLs发展的新趋势。 Based on the drug-resistance characters of IRBLs,we studied the prevalence of IRBLs among 40 clinical isolates in duck E.coli was studied by K-B test and the drug-resistance of IRBLs-producer to antibacterial drugs was analyzed.The results showed that 4 isolates produced IRBLs,with resistance to amoxi-cillin,amoxicillin/clavulanic acid,ampicillin,ampicillin/sulbactam,ticarcillin/clavulanicacid,florfenicol,gentamycin,neomycin,sulfadiazine and doxycycline,which suggested that IRBLs-producing isolates had emerged in China,and were characterized by multidrug-resistance.Besides,two IRBLs-producing strains were susceptible to piperacillin/tazobactam,resulting from the protection of tazobactam to piperacillin.What＇s more,there was one IRBLs-producing strain which was resistant to the third generation cephalosporins,which explained it may also produced ESBLs or AmpC,and it implyed the further development trend about IRBLs.

关 键 词： 鸭大肠杆菌 耐酶抑制剂 内酰胺酶 纸片扩散法 耐药性

领　　域： [农业科学] [农业科学]