作　　者： ; ;

机构地区： 重庆大学生物医学工程联合学院

出　　处： 《细胞生物学杂志》 2009年第6期761-766,共6页

摘　　要： CXCR7[chemokine(C-X-C motif)receptor 7]/是一个新发现的基质细胞衍生因子-1(stroma-cell drived factor 1,SDF-1)受体。在SDF-1调控的生命过程中,它发挥着与CXCR4不尽相同但又相互协调的重要作用。CXCR7与细胞的存活、增殖、分化发育以及粘附和运动具有密切的关系,并在肿瘤发生、血管生成和免疫反应中起着重要的作用。在综述已有对CXCR7研究的基础上,本文探讨了CXCR7在肿瘤发生、血管生成和免疫反应中可能的作用机制,以及作为相关疾病治疗靶标的潜力。 CXCR7 [chemokine （C-X-C motif） receptor 7] is a newly defined stroma-cell drived factor 1 （SDF-1） receptor. In these biological processes mediated by SDF-1, CXCR7 plays a different but synergistic role as compared with that of CXCR4. CXCR7 has close correlation with cell survival, proliferation, differentiation or functional maturation as well as cell adhesion and migration, and plays a critical role in tumor development, angiogenesis, and immunological responses. In this review, we provided an overview of the major findings on CXCR7 and then, a description of the potential action mechanism of CXCR7 in tumor development, angiogenesis, and immunological responses. We also displayed its potential as a therapy target for relative diseases.

关 键 词： 基质细胞衍生因子 肿瘤 血管生成 免疫

领　　域： [生物学] [农业科学] [农业科学] [农业科学]