作　　者： ; ; ;

机构地区： 湖南科技大学体育学院

出　　处： 《山东体育学院学报》 2009年第11期39-42,共4页

摘　　要： 目的:探索不同强度的有氧运动对动脉粥样硬化大鼠血液NO信号的影响以及一些相关调节因素的变化。方法:60只SD大鼠随机分为C组、AS组、ASL组、ASM组、ASH,每组10只。运动组的跑速分别设计为10 m/min、15 m/min、20 m/min,每天一次训练,时间为30分钟,运动实验持续时间为4周,每周训练6天。运动结束后处死大鼠,测定血清一氧化氮(nitric oxide,NO)、一氧化氮合酶(nitric oxide synthase,NOS)、内皮素(endothelin,ET)、左旋精氨酸(L-arginine,L-Arg)和非对称二甲基精氨酸(Asymmetrical Dimethylarginine,ADMA)浓度。结果:1)无论何种强度的有氧运动均可以显著提高血清NO水平,但是中等强度以上的有氧运动效果更为明显;中等强度的有氧运动可明显提高血清NOS的含量;低强度虽然也升高了ET水平,但是中等以上强度效果更为明显。2)动脉粥样硬化发展过程中,L-Arg浓度变化并不明显,ADMA水平明显上升。各种强度的有氧练习也不会升高血清L-Arg水平,但是较大的强度有利于降低血清ADMA水平,并有效改善L-Arg/ADMA比值,因此较大强度的有氧练习可能对NO的释放有明显的改善。结论:中等以上强度的有氧练习对改善动脉粥样硬化大鼠的NO信号和相关的调节分子的效果更为明显。 Objective：Explore the effect of different intensity aerobic exercise on serum NO signal and relative factory in artherosclerosis rat. Method： 60 rats were divided into five groups including C group （control group ）, AS group （artherosclerosis） ,ASL group （artherosclerosis and low intensity aerobic exercise ）, ASM group （artherosclerosis and Moderately intensity aerobic exercise） and ASH group has 10 rats. The speed of three exercising The experiment of exercise persist four weeks, 6 group （artherosclerosis and high intensity aerobic exercise）, and each groups design as 10m/min, 15 m/min and 20 m/rain, lasting 30 min. days of each week. After the experiment of exercise all rats should be killed and the concentrateion of serum NO, NOS, ET, L - Arg and ADMA should be measured. Result： 1. All kinds of exercise intensities can notable improve the concentration of serum NO, however, the effect is more obviously when the intensity exceed medium intensity. Moderately intensity aerobic exercise can obviously improve the serum NOS content. When the intensity exceed medium intensity, the effect of ET concentration increase is more obvious than the low intensity aerobic exercise. 2. The concentration of L - Arg is not chang during artherosclerosis developing . All kinds of intensity exercise can not increase the L -Arg concentration. On the other hand, higher intensity aerobic exercise can depress the serum concentration of ADMA and visible improve the ratio of L - Arg/ADMA. Therefore, the higher intensity of aerobic exercise can obviously improve the NO release of artherosclerosis rat. Conclusion： The effect of improve NO signal and relative factory in artherosclerosis rat is most obviously when those rats execute aerobic exercise over Moderately intensity.

关 键 词： 动脉粥样硬化 运动 一氧化氮 非对称二甲基精氨酸 左旋精氨酸

领　　域： [文化科学] [文化科学]