作　　者： ; ; (田长恩）;

机构地区： 广州大学生命科学学院

出　　处： 《广东化工》 2009年第11期227-229,共3页

摘　　要： 建立了褐黄孢链霉菌分批发酵生产纳他霉素过程基于非结构模型的菌体生长、基质消耗和产物形成的动力学方程。模型验证实验数据表明,在0～80h内模型值与实验值拟合良好。据此采取分段控制的调控策略,30L发酵罐中发酵80h纳他霉素产量达4.41g/L,综合考虑发酵周期等因素,文章结果已达较高水平。 Batch fermentation of Streptomyces gilvosporeus GXLZ-96 for natamycine production was carried out in the paper. Mathematical kinetic model describing the time-course of biomass, products and substrates were obtained based on the unstructured model of biochemical process. The results showed that these models fit for the experimental data quiet well during the first 80 h of the batch fermentation process of Streptomyces gilvosporeus GXLZ-96 for natamycine production in a 30 L bioreactor according to the kinetics studies, the accumulation of natamycine reached 4.41 g/L which surpassed the highest level in the same fermentation duration reported so far.

关 键 词： 褐黄孢链霉菌 分批发酵 非结构模型 发酵动力学

领　　域： [轻工技术与工程] [轻工技术与工程] [自动化与计算机技术] [自动化与计算机技术]