作 者: ;
机构地区: 四川农业大学动物科技学院
出 处: 《畜牧兽医学报》 1998年第4期377-384,共8页
摘 要: 40只雏鹅口服感染小鹅瘟病毒,在不同感染阶段剖杀雏鹅,观察各组织器官的病理变化发展规律及病理特征。接种后第1天,小肠绒毛顶部上皮首先发生坏死脱落。随着感染时间的延长,坏死、脱落向绒毛基部发展,同时,固有膜也相继发生坏死和炎性细胞浸润。由于小肠的坏死和炎性渗出逐步加剧,最后发展成为纤维素性坏死性肠炎,并在小肠的中下段形成特征性的凝固性栓子,堵满肠腔。实质器官普遍发生变性和炎性细胞浸润。肝、胰、脾、胸腺、腔上囊,发生灶性坏死。电镜观察,病毒首先损害小肠绒毛顶部上皮,心肌和肝细胞线粒体肿胀,嵴断裂,消失,基质变空,内质网扩张,核染色质溶解。 お?0 fivedayold goslings were experimentally infected with gosling plague virus by oral administrationThe infected goslings were killed at distinct postinfection stagesThe first changes were found in the small intestineThe epithelial cells at the villus tip fell off on the first day postinfectionThen necrosis and slough went down to the bases of the villusMeanwhile,the necrosis and infiltration with the inflammatory cells occurred in the membrana propriaAlong with the aggravatin of these changes,the fibrinous necrotic enteritis appeared in the small intestine ,especially,in the middlelower sections of the small intestineAs a result,a particular coagulative embolus occurred and blocked up the intestinal cavityParenchymatous organs showed degeneration and infiltration with the inflammatory cellsFacal necrosis was seen in the liver,spleen,pancreas,thymus,bursa of FabriciusObservation throught electron microscope proved that the virus first affected the epithelial cells at the villus tip of the small intestinesThe mitochondria in the cells of the heart and liver swelledThe crest became short or disappeared,and ground substance emptiedAlso,endoplasmic reticulum dilated