作　　者： ; ; ; ;

机构地区： 第二军医大学

出　　处： 《实验动物与比较医学》 2009年第3期185-191,共7页

摘　　要： 目的在大鼠硒性白内障动物模型制备情况的基础上，结合评价指标体系建立原则，综合人类疾病动物模型的复制原则，设计出一套大鼠硒性白内障动物模型制备效果评价指标体系。方法通过文献调研，搜集了评价大鼠硒性白内障动物模型制备效果的26个调研指标。根据调研结果，针对大鼠硒性白内障动物模型制备过程中影响其效果的各种因素，耦合德尔菲法和层次分析法，建立了大鼠硒性白内障动物模型制备效果评价指标体系和模型。结果通过实证，确认该评价体系良好。结论本研究建立的评价指标体系清晰、简便，利于科研人员使用。 Objective To design the evaluation index system of preparation efficacy on sodium- selenite-induced cataract in neonate rats, on the basis of the animal models＇ establishment, combined with the establishment principle of evaluation index system and the preparation principle of animal models of human disease. Methods Through literature research, 26 indicators for evaluating the system for sodium-selenite-induced cataract in neonate rats were collected. According to the research report and the effects of various factors on the preparation of sodium-selenite-induced cataract in neonate rats, coupled with Delphi method and AHP（analytic hierarchy process）, we designed the preparation effect evaluation index system and established the animal model. Results Through the evidence, the evalua- tion index system was confirmed as a good system. Condution The evaluation index system set up in this study was a clear, simple and easy-to-use system.

关 键 词： 硒性白内障 动物模型 德尔菲法 层次分析法 评价指标体系

领　　域： [生物学]