作　　者： ; ; ;

机构地区： 肇庆学院体育与健康学院

出　　处： 《山东体育学院学报》 2009年第5期24-28,共5页

摘　　要： 使用跑台及低氧舱对SD大鼠进行了低氧、力竭实验，同时检测运动后即刻、1、2、4及7天大鼠骨骼肌SOD、MDA及线粒体钙的浓度，以探讨低氧、运动对其影响。结果发现：1）急性低氧、常氧运动后随着时相的不同，SOD、MDA均表现出先升高后下降的趋势，到第7天基本恢复正常，总体趋势是至7天时自由基与抗自由基系统逐渐恢复平衡，运动后常氧下更有利于自由基的清除。2）急性常氧、低氧力竭运动引起的线粒体钙与MDA的变化相似，均表现在运动后即刻有显著性增加，运动后24小时变化最明显，同时达到最高值，运动后48小时开始下降，4—7天基本恢复正常。3）从本研究结果可以推测低氧、力竭运动后可导致骨骼肌活性氧增加及钙离子内环境紊乱，但低氧和运动的双重作用不会使上述变化加重。 The purpose of this study was to investigate skeletal muscle of SD rats under hypoxia and exhausting exercises by the treadmill and hypoxic chamber. At the same time, the sduty investigated SOD, MDA and MCC concentration of the groups of SD rats（killed on 0, 1, 2, 4, 7 days after exercise）, and researched Hypoxia, exhausting exercise effect on theirs. The results showed that 1） After hypoxic exhausting exercise and exhausting exercise, their SOD and MDA entirely showed that they firstly increased, and then decreased in the subsequently different time. In the seven day, their SOD and MDA basically recovered to the normal value, and their total tendency showed that the system of free radical and anti- free radical gradually recovered balance in the seven day. But exhausting exercise groups＇ free radical was more easily cleared away. 2）OE and He groups＇ the changes of MCC were similar to those of MDA, they all significantly increased immediately after eccentric exercise, and reached maximum at 24 hour after eccentric exercise, and began to descrease at 48h after eccentric exercise, basically recovered from 4d to 7d. 3）He and OE groups perhaps were induced by dysfunction of the calcium ion＇s homeostasis, and/or by an increase of ROS at post- exercise. The results showed that the process of the skeletal muscle injuries of the rats under hypoxia was consistent with those under the normoxic condition and that hypoxia was unable to obviously accelerate or deepen the skeletal muscle changes following a single bout of high- intensity exercise.

关 键 词： 骨骼肌 低氧 力竭运动 线粒体钙

领　　域： [文化科学] [文化科学]