机构地区: 中山大学化学与化学工程学院
出 处: 《化学进展》 2009年第5期836-844,共9页
摘 要: 钌配合物作为抗癌药物的研究已受到广泛关注,成为无机药物化学的重要研究内容之一。本文简要评述了近年来钌配合物的抗肿瘤活性研究进展,包括作为细胞毒药物的钌配合物设计与筛选、钌配合物以端粒酶、DNA拓扑异构酶及蛋白激酶作为抗肿瘤作用新靶点等。 The study of ruthenium complexes as antitumor drugs has received intense interest and become an important research field of medicinal inorganic chemistry. This review highlights some recent progresses in the antitumor activity of ruthenium complexes, including the design and screening of ruthenium complexes as cytotoxic drugs, and the inhibition of telomerase, topoisomerase and protein kinase with ruthenium complexes.