作　　者： ; ;

机构地区： 中国人民解放军白求恩军医学院

出　　处： 《生命的化学》 2009年第2期275-278,共4页

摘　　要： Stra8(stimulated by retinoic acid gene8)是一种生殖细胞特异性表达并受视黄酸诱导的基因,它可有效促进生殖细胞启动减数分裂。Stra8是减数分裂起始的调节蛋白,参与了雌性胚胎期和雄性出生后生殖细胞的减数分裂起始过程。胚胎期睾丸减数分裂起始受阻是由于视黄酸降解酶CYP26B1和发育相关调节蛋白Nanos2抑制Stra8表达的结果。Stra8与生殖细胞减数分裂起始的研究有助于人们对精子生成和卵子发育的深入理解。 Stra8 （stimulated by retinoic acid gene 8） is a germ cell-specific gene and can initiate meiosis of germ cell, whose expression is induced by retinoic acid. Stra8 is a regulator of meiotic initiation in female embryonic and male postnatal germ cells. Meiosis is retarded in the fetal testis by the retinoid-degrading enzyme CYP26B 1 and development-related regulator Nanos 2, which can inhibit the expression of Stra8. These studies on Stra8 and meiotic initiation are beneficial to the understanding for spermatogenesis and oogenesis.

关 键 词： 视黄酸 生殖细胞 减数分裂

领　　域： [生物学]